Kinetics of protective antibodies are determined by the viral surface antigen

Delayed and weak virus neutralizing antibody (nAb) responses represent a hallmark correlating not only with the establishment of persistent infection but also with unsuccessful vaccine development. Using a reverse genetic approach, we evaluated possible underlying mechanisms in 2 widely studied vira...

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Main Authors: Pinschewer, Daniel D., Perez, Mar, Jeetendra, Eswaraka, Bächi, Thomas, Horvath, Edit, Hengartner, Hans, Whitt, Michael A., de la Torre, Juan Carlos, Zinkernagel, Rolf M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC518669/
https://ncbi.nlm.nih.gov/pubmed/15467838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422374
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