FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons

Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is primarily localized in the nucleus and is involved in c...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Higelin, Julia, Demestre, Maria, Putz, Stefan, Delling, Jan P., Jacob, Christian, Lutz, Anne-Kathrin, Bausinger, Julia, Huber, Anne-Kathrin, Klingenstein, Moritz, Barbi, Gotthold, Speit, Günter, Huebers, Annemarie, Weishaupt, Jochen H., Hermann, Andreas, Liebau, Stefan, Ludolph, Albert C., Boeckers, Tobias M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183648/
https://ncbi.nlm.nih.gov/pubmed/28082870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00290
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