Blockade of Serotonin 5-HT(2A) Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice

The increasing prescription of opioids is fueling an epidemic of addiction and overdose deaths. Morphine is a highly addictive drug characterized by a high relapse rate – even after a long period of abstinence. Serotonin (5-HT) neurotransmission participates in the development of morphine dependence...

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Publicat a:Front Pharmacol
Autors principals: Pang, Gang, Wu, Xian, Tao, Xinrong, Mao, Ruoying, Liu, Xueke, Zhang, Yong-Mei, Li, Guangwu, Stackman, Robert W., Dong, Liuyi, Zhang, Gongliang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183621/
https://ncbi.nlm.nih.gov/pubmed/28082900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00514
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