BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis

Neurotrophin receptors mediate a plethora of signals affecting neuronal survival. The p75 pan-neurotrophin receptor controls neuronal cell fate after its selective activation by immature and mature isoforms of all neurotrophins. It also exerts pleiotropic effects interacting with a variety of ligand...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Pediaditakis, Iosif, Kourgiantaki, Alexandra, Prousis, Kyriakos C., Potamitis, Constantinos, Xanthopoulos, Kleanthis P., Zervou, Maria, Calogeropoulou, Theodora, Charalampopoulos, Ioannis, Gravanis, Achille
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183592/
https://ncbi.nlm.nih.gov/pubmed/28082899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00512
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