Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival TrkA and pro-death p75(NTR) membrane receptor...

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Detalhes bibliográficos
Main Authors: Lazaridis, Iakovos, Charalampopoulos, Ioannis, Alexaki, Vassilia-Ismini, Avlonitis, Nicolaos, Pediaditakis, Iosif, Efstathopoulos, Paschalis, Calogeropoulou, Theodora, Castanas, Elias, Gravanis, Achille
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082517/
https://ncbi.nlm.nih.gov/pubmed/21541365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001051
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