Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival TrkA and pro-death p75(NTR) membrane receptor...

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Bibliographic Details
Main Authors: Lazaridis, Iakovos, Charalampopoulos, Ioannis, Alexaki, Vassilia-Ismini, Avlonitis, Nicolaos, Pediaditakis, Iosif, Efstathopoulos, Paschalis, Calogeropoulou, Theodora, Castanas, Elias, Gravanis, Achille
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082517/
https://ncbi.nlm.nih.gov/pubmed/21541365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001051
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