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Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB(+1)

The ubiquitin mutant UBB(+1) has been identified as a hallmark of neurodegenerative disease. In this study, we characterize polyubiquitinated forms of UBB(+1) in vitro and from patient samples. The ability of UBB(+1) to be readily ubiquitinated by several E2 enzymes provided a mechanism for the cont...

詳細記述

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書誌詳細
出版年:FEBS Lett
主要な著者: Chojnacki, Michal, Zhang, Daoning, Talarowska, Monika, Gałecki, Piotr, Szemraj, Janusz, Fushman, David, Nakasone, Mark A.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182158/
https://ncbi.nlm.nih.gov/pubmed/27861798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12484
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