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Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB(+1)
The ubiquitin mutant UBB(+1) has been identified as a hallmark of neurodegenerative disease. In this study, we characterize polyubiquitinated forms of UBB(+1) in vitro and from patient samples. The ability of UBB(+1) to be readily ubiquitinated by several E2 enzymes provided a mechanism for the cont...
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| Publié dans: | FEBS Lett |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5182158/ https://ncbi.nlm.nih.gov/pubmed/27861798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12484 |
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