LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

Signaling and post-transcriptional gene control are both critical for the regulation of pluripotency(1,2), yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein (RBP), has emerged as a central post-trans...

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Udgivet i:Nat Cell Biol
Main Authors: Tsanov, Kaloyan M., Pearson, Daniel S., Wu, Zhaoting, Han, Areum, Triboulet, Robinson, Seligson, Marc T., Powers, John T., Osborne, Jihan K., Kane, Susan, Gygi, Steven P., Gregory, Richard I., Daley, George Q.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182091/
https://ncbi.nlm.nih.gov/pubmed/27992407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3453
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