Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 and BACHD models of HD. Using diffusion tensor magne...

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Publicado en:Hum Mol Genet
Main Authors: Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181633/
https://ncbi.nlm.nih.gov/pubmed/27126634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw122
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