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Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling
Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. In our previous studies, we find that inhibition of FPPS attenuates angiotensin II-induced cardiac hypertrophy and fibrosis by suppressing RhoA while FPPS and Ras are up-regulated in pressure overload rats. In this stu...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5180215/ https://ncbi.nlm.nih.gov/pubmed/28008986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39186 |
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