Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling

Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. In our previous studies, we find that inhibition of FPPS attenuates angiotensin II-induced cardiac hypertrophy and fibrosis by suppressing RhoA while FPPS and Ras are up-regulated in pressure overload rats. In this stu...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Zhao, Chen-Ze, Zhao, Xu-Ming, Yang, Jian, Mou, Yun, Chen, Bin, Wu, Huan-Dong, Dai, Dong-Pu, Ding, Jie, Hu, Shen-Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180215/
https://ncbi.nlm.nih.gov/pubmed/28008986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39186
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