Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease

BACKGROUND: Epithelial-mesenchymal transition (EMT) and cyclooxygenase-2 (COX-2) contribute to airway remodelling and inflammation in chronic obstructive pulmonary disease (COPD). Recent data suggest that the farnesoid X receptor (FXR), a nuclear receptor traditionally considered as bile acid-activa...

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Detalhes bibliográficos
Publicado no:J Thorac Dis
Main Authors: Chen, Bi, You, Wen-Jie, Xue, Shan, Qin, Hui, Zhao, Xu-Ji, Zhang, Miao, Liu, Xue-Qing, Zhu, Shu-Yang, Jiang, Han-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179405/
https://ncbi.nlm.nih.gov/pubmed/28066584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2016.11.08
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