Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2″-Ether Analogues

Novel amphiphilic aminoglycosides are shown to inhibit clinically relevant deactivating enzymes, without undergoing significant deactivation themselves. [Image: see text]

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Szychowski, Janek, Kondo, Jiro, Zahr, Omar, Auclair, Karine, Westhof, Eric, Hanessian, Stephen, Keillor, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179253/
https://ncbi.nlm.nih.gov/pubmed/21905229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100346
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