Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization

Brd4 is a mammalian protein that contains a double bromodomain. It binds to chromatin and regulates cell cycle progression at multiple stages. By immunopurification and mass spectrometry, we identified a Rap GTPase-activating protein (GAP), signal-induced proliferation-associated protein 1 (SPA-1),...

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Autores principales: Farina, Andrea, Hattori, Masakazu, Qin, Jun, Nakatani, Yoshihiro, Minato, Nagahiro, Ozato, Keiko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC517877/
https://ncbi.nlm.nih.gov/pubmed/15456879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.9059-9069.2004
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