Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells

It has been reported that DNA methyltransferase 1-deficient (Dnmt1(−/−)) embryonic stem (ES) cells are hypomethylated (20% CpG methylation) and die through apoptosis when induced to differentiate. Here, we show that Dnmt[3a(−/−),3b(−/−)] ES cells with just 0.6% of their CpG dinucleotides behave diff...

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Bibliographic Details
Main Authors: Jackson, Melany, Krassowska, Anna, Gilbert, Nick, Chevassut, Timothy, Forrester, Lesley, Ansell, John, Ramsahoye, Bernard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC517875/
https://ncbi.nlm.nih.gov/pubmed/15456861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.8862-8871.2004
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