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Disruption of the myocardial extracellular matrix leads to cardiac dysfunction

MMP activity with disruption of structural collagen has been implicated in the pathophysiology of dilated cardiomyopathy. To examine the role of this enzyme in cardiac function, a transgenic mouse was created that constitutively expressed human collagenase (MMP-1) in the heart. At 6 months of age, t...

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Detalhes bibliográficos
Main Authors: Kim, Henry E., Dalal, Seema S., Young, Erik, Legato, Marianne J., Weisfeldt, Myron L., D’Armiento, Jeanine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517818/
https://ncbi.nlm.nih.gov/pubmed/11018073
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