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Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord

Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine-induced antinociceptive tolerance. However, its exact effect and molecular mechanism remai...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Dai, Wen-Ling, Xiong, Feng, Yan, Bing, Cao, Zheng-Yu, Liu, Wen-Tao, Liu, Ji-Hua, Yu, Bo-Yang
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177930/
https://ncbi.nlm.nih.gov/pubmed/28004735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38746
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