ERK-mediated NF-κB activation through ASIC1 in response to acidosis

Acidic microenvironment is a common feature of solid tumors. We have previously shown that neuron specific acid-sensing ion channel 1 (ASIC1) is expressed in breast cancer, and it is responsible for acidosis-induced cellular signaling through AKT, leading to nuclear factor-κB (NF-κB) activation, and...

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Publicado en:Oncogenesis
Autores principales: Chen, B, Liu, J, Ho, T-T, Ding, X, Mo, Y-Y
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177778/
https://ncbi.nlm.nih.gov/pubmed/27941930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.81
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