Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs

Calcium and iron overload participate in the mechanisms of ischemia/reperfusion (I/R) injury during myocardial infarction (MI). Calcium overload induces cardiomyocyte death by hypercontraction, while iron catalyses generation of reactive oxygen species (ROS). We therefore hypothesized that dexrazoxa...

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Publicado en:PLoS One
Autores principales: Kamat, Pranitha, Vandenberghe, Stijn, Christen, Stephan, Bongoni, Anjan K., Meier, Bernhard, Rieben, Robert, Khattab, Ahmed A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176296/
https://ncbi.nlm.nih.gov/pubmed/28002439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168541
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