Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs

Calcium and iron overload participate in the mechanisms of ischemia/reperfusion (I/R) injury during myocardial infarction (MI). Calcium overload induces cardiomyocyte death by hypercontraction, while iron catalyses generation of reactive oxygen species (ROS). We therefore hypothesized that dexrazoxa...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Kamat, Pranitha, Vandenberghe, Stijn, Christen, Stephan, Bongoni, Anjan K., Meier, Bernhard, Rieben, Robert, Khattab, Ahmed A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176296/
https://ncbi.nlm.nih.gov/pubmed/28002439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168541
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