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Retinal Conformation Governs pK(a) of Protonated Schiff Base in Rhodopsin Activation
We have explored the relationship between conformational energetics and the protonation state of the Schiff base in retinal, the covalently bound ligand responsible for activating the G protein–coupled receptor rhodopsin, using quantum chemical calculations. Guided by experimental structural determi...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5176254/ https://ncbi.nlm.nih.gov/pubmed/23701524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4002986 |
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