Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, the adjuvant activity of aluminum salts may not be potent...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Fox, Christopher B., Orr, Mark T., Van Hoeven, Neal, Parker, Sarah C., Mikasa, Traci J.T., Phan, Tony, Beebe, Elyse A., Nana, Ghislain I., Joshi, Sharvari W, Tomai, Mark A., Elvecrog, James, Fouts, Timothy R., Reed, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publishers 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176129/
https://ncbi.nlm.nih.gov/pubmed/27847326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.11.011
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