A Druggable TCF4 and BRD4 dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). Using RNA interference screening, we identified the E-box transcription factor TCF4 as a master regulator of the BPDCN oncogenic pr...

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Pubblicato in:Cancer Cell
Autori principali: Ceribelli, Michele, Hou, Zhiying Esther, Kelly, Priscilla N., Huang, Da Wei, Wright, George, Ganapathi, Karthik, Evbuomwan, Moses O., Pittaluga, Stefania, Shaffer, Arthur L., Marcucci, Guido, Forman, Stephen J., Xiao, Wenming, Guha, Rajarshi, Zhang, Xiaohu, Ferrer, Marc, Chaperot, Laurence, Plumas, Joel, Jaffe, Elaine S., Thomas, Craig J., Reizis, Boris, Staudt, Louis M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175469/
https://ncbi.nlm.nih.gov/pubmed/27846392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.002
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