Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease

Aims: Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various d...

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Bibliographic Details
Published in:Antioxid Redox Signal
Main Authors: Gorelenkova Miller, Olga, Behring, Jessica Belle, Siedlak, Sandra L., Jiang, Sirui, Matsui, Reiko, Bachschmid, Markus M., Zhu, Xiongwei, Mieyal, John J.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2016
Subjects:
Original Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175443/
https://ncbi.nlm.nih.gov/pubmed/27224303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6598
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