Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Although the precise mechanism underlying initial lesion development in multiple sclerosis (MS) remains unclear, CNS inflammation has long been associated with demyelination, and axonal degeneration. The activation of microglia/macrophages, which serve as innate immune cells in the CNS, is the first...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Liang, Junjie, Li, Ning, Zhang, Yanli, Hou, Changyi, Yang, Xiaohan, Shimizu, Takahiro, Wang, Xiaoyu, Ikenaka, Kazuhiro, Fan, Kai, Ma, Jianmei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175397/
https://ncbi.nlm.nih.gov/pubmed/28066178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00152
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