Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Although the precise mechanism underlying initial lesion development in multiple sclerosis (MS) remains unclear, CNS inflammation has long been associated with demyelination, and axonal degeneration. The activation of microglia/macrophages, which serve as innate immune cells in the CNS, is the first...

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Udgivet i:Front Mol Neurosci
Main Authors: Liang, Junjie, Li, Ning, Zhang, Yanli, Hou, Changyi, Yang, Xiaohan, Shimizu, Takahiro, Wang, Xiaoyu, Ikenaka, Kazuhiro, Fan, Kai, Ma, Jianmei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175397/
https://ncbi.nlm.nih.gov/pubmed/28066178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00152
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