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Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

Delivery of nonlipophilic drugs to the brain is hindered by the tightly apposed capillary endothelial cells that make up the blood-brain barrier. We have examined the ability of a monoclonal antibody (OX-26), which recognizes the rat transferrin receptor, to function as a carrier for the delivery of...

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Hlavní autoři: Friden, P M, Walus, L R, Musso, G F, Taylor, M A, Malfroy, B, Starzyk, R M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1991
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC51748/
https://ncbi.nlm.nih.gov/pubmed/2052557
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