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Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-ef...

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Автори: Demi M. Castellanos, Jiahong Sun, Joshua Yang, Weijun Ou, Alexander C. Zambon, William M. Pardridge, Rachita K. Sumbria
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2020-09-01
Серія:Pharmaceutics
Предмети:
transferrin receptor
transferrin receptor monoclonal antibody
iron
blood-brain barrier
pharmacokinetics
reticulocytes
Онлайн доступ:https://www.mdpi.com/1999-4923/12/9/852
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