Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-ef...

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Autori principali:	Demi M. Castellanos, Jiahong Sun, Joshua Yang, Weijun Ou, Alexander C. Zambon, William M. Pardridge, Rachita K. Sumbria
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-09-01
Serie:	Pharmaceutics
Soggetti:	transferrin receptor transferrin receptor monoclonal antibody iron blood-brain barrier pharmacokinetics reticulocytes
Accesso online:	https://www.mdpi.com/1999-4923/12/9/852
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