BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo

Deletion of various bone morphogenetic proteins (BMPs) and their downstream Smads in mice have clearly shown that BMP signaling is essential for the formation of primordial germ cells (PGCs). However, the molecular mechanism through which this takes place is still unclear. Here, we demonstrate that...

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Detalhes bibliográficos
Main Authors: de Sousa Lopes, Susana M. Chuva, Roelen, Bernard A.J., Monteiro, Rui M., Emmens, Roul, Lin, Herbert Y., Li, En, Lawson, Kirstie A., Mummery, Christine L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517404/
https://ncbi.nlm.nih.gov/pubmed/15289457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.294004
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