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Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo

Endocytosed nicotinic acetylcholine receptors (CHRN) are degraded via macroautophagy/autophagy during atrophic conditions and are accompanied by the autophagic regulator protein SH3GLB1. The present study addressed the functional role of SH3GLB1 on CHRN trafficking and its implementation. We found a...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Wild, Franziska, Khan, Muzamil Majid, Straka, Tatjana, Rudolf, Rüdiger
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173261/
https://ncbi.nlm.nih.gov/pubmed/27715385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1234564
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