PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma

Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single-stranded phosphodiester DNA oligodeoxynucleotide (PNT100) encapsulated in a protective liposome, was precisely designed to treat cancers that over-express BCL-2. PNT2258...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Ebrahim, Abdul Shukkur, Kandouz, Mustapha, Liddane, Allison, Sabbagh, Hussam, Hou, Yuning, Li, Chunying, Al-Katib, Ayad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173141/
https://ncbi.nlm.nih.gov/pubmed/27283896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9872
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