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Unintended target effect of anti-BCL-2 DNAi
INTRODUCTION: Previous research suggested that a novel compound PNT2258 inhibits B-cell lymphoma 2 (BCL-2) transcription by DNA interference (DNAi) and demonstrated its activity in preclinical xenograft models and in a pilot Phase II clinical trial in non-Hodgkin’s lymphoma (NHL). While the drug dow...
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| Publicado no: | Cancer Manag Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5624602/ https://ncbi.nlm.nih.gov/pubmed/28989285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S139105 |
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