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Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.

B19 parvovirus is pathogenic in humans, causing fifth disease, transient aplastic crisis, some cases of hydrops fetalis, and acquired pure red cell aplasia. Efforts to develop serologic assays and vaccine development have been hampered by the virus's extreme tropism for human bone marrow and the abs...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kajigaya, S, Fujii, H, Field, A, Anderson, S, Rosenfeld, S, Anderson, L J, Shimada, T, Young, N S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51722/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1711206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4646
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