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Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.

B19 parvovirus is pathogenic in humans, causing fifth disease, transient aplastic crisis, some cases of hydrops fetalis, and acquired pure red cell aplasia. Efforts to develop serologic assays and vaccine development have been hampered by the virus's extreme tropism for human bone marrow and the abs...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Kajigaya, S, Fujii, H, Field, A, Anderson, S, Rosenfeld, S, Anderson, L J, Shimada, T, Young, N S
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1991
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51722/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1711206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4646
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