Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. In mice, cardiac stress...

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Publicado no:Nat Commun
Main Authors: Yang, Jin, Savvatis, Konstantinos, Kang, Jong Seok, Fan, Peidong, Zhong, Hongyan, Schwartz, Karen, Barry, Vivian, Mikels-Vigdal, Amanda, Karpinski, Serge, Kornyeyev, Dmytro, Adamkewicz, Joanne, Feng, Xuhui, Zhou, Qiong, Shang, Ching, Kumar, Praveen, Phan, Dillon, Kasner, Mario, López, Begoña, Diez, Javier, Wright, Keith C., Kovacs, Roxanne L., Chen, Peng-Sheng, Quertermous, Thomas, Smith, Victoria, Yao, Lina, Tschöpe, Carsten, Chang, Ching-Pin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171850/
https://ncbi.nlm.nih.gov/pubmed/27966531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13710
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