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Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa

Plant knottins are of therapeutic interest due to their high metabolic stability and inhibitory activity against proteinases involved in human diseases. The only knottin-type proteinase inhibitor against porcine pancreatic elastase was first identified from the squash family in 1989. Here, we report...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Loo, Shining, Kam, Antony, Xiao, Tianshu, Nguyen, Giang K. T., Liu, Chuan Fa, Tam, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171801/
https://ncbi.nlm.nih.gov/pubmed/27991569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39401
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