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Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein E-conjugated liposomes to the hippocampus

β-Amyloid (Aβ)-targeting liposomes (LIP) with surface serotonin modulator (SM) and apolipoprotein E (ApoE) were utilized to facilitate the delivery of nerve growth factor (NGF) across the blood–brain barrier (BBB) for neuroprotection in the hippocampus. The therapeutic efficacy of SM- and ApoE-graft...

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Publicat a:Int J Nanomedicine
Autors principals: Kuo, Yung-Chih, Lee, Yin-Jung
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5170675/
https://ncbi.nlm.nih.gov/pubmed/28008255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S123442
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