A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin

PURPOSE: The analgesic and opioid-sparing effects of nonsteroidal anti-inflammatory drugs can be beneficial in postoperative populations. Hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac is an injectable formulation of diclofenac solubilized with HPβCD that is administered as a low-volume intravenous...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacol
Hauptverfasser: Goldwater, Ronald, Kramer, William G, Hamilton, Douglas A, Lang, Eric, Wang, Jianyuan, Madden, Donna E, Lacouture, Peter G, Ramaiya, Atulkumar, Carr, Daniel B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5170674/
https://ncbi.nlm.nih.gov/pubmed/28008289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S98437
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