Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunction are poorly understood. We found that toxic lipids relevant to three different LSDs disrupt multiple lysosomal and other cellular functions. Unbiased drug discovery revealed...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Folts, Christopher J., Scott-Hewitt, Nicole, Pröschel, Christoph, Mayer-Pröschel, Margot, Noble, Mark
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5169359/
https://ncbi.nlm.nih.gov/pubmed/27977664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002583
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