Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It is caused by mutations in the inflammasome adaptor Pyrin, but how FMF mutations alter signaling in FMF patients is unknown. Herein, we establish Clostridium difficile and its enterotoxin A (TcdA) a...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Van Gorp, Hanne, Saavedra, Pedro H. V., de Vasconcelos, Nathalia M., Van Opdenbosch, Nina, Vande Walle, Lieselotte, Matusiak, Magdalena, Prencipe, Giusi, Insalaco, Antonella, Van Hauwermeiren, Filip, Demon, Dieter, Bogaert, Delfien J., Dullaers, Melissa, De Baere, Elfride, Hochepied, Tino, Dehoorne, Joke, Vermaelen, Karim Y., Haerynck, Filomeen, De Benedetti, Fabrizio, Lamkanfi, Mohamed
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167202/
https://ncbi.nlm.nih.gov/pubmed/27911804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613156113
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