Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It is caused by mutations in the inflammasome adaptor Pyrin, but how FMF mutations alter signaling in FMF patients is unknown. Herein, we establish Clostridium difficile and its enterotoxin A (TcdA) a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Van Gorp, Hanne, Saavedra, Pedro H. V., de Vasconcelos, Nathalia M., Van Opdenbosch, Nina, Vande Walle, Lieselotte, Matusiak, Magdalena, Prencipe, Giusi, Insalaco, Antonella, Van Hauwermeiren, Filip, Demon, Dieter, Bogaert, Delfien J., Dullaers, Melissa, De Baere, Elfride, Hochepied, Tino, Dehoorne, Joke, Vermaelen, Karim Y., Haerynck, Filomeen, De Benedetti, Fabrizio, Lamkanfi, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167202/
https://ncbi.nlm.nih.gov/pubmed/27911804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613156113
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