MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1–IRF3 signaling axis

The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is kn...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Seo, Minji, Lee, Seong-Ok, Kim, Ji-Hoon, Hong, Yujin, Kim, Seongchan, Kim, Yeumin, Min, Dal-Hee, Kong, Young-Yun, Shin, Jinwook, Ahn, Kwangseog
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167196/
https://ncbi.nlm.nih.gov/pubmed/27911820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615287113
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