Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression

Nucleophosmin (NPM1) - a gene that encodes for a nuclear protein with multiple functions. Mutations in NPM1 are seen in approximately one-third of acute myeloid leukemia (AML) and are generally associated with good response to induction chemotherapy. However, the mechanisms underlying this chemosens...

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Publicat a:J Cancer
Autors principals: Zhang, Shuaishuai, Qin, Fengxian, Yang, Liyuan, Xian, Jingrong, Zou, Qin, Jin, Hongjun, Wang, Lu, Zhang, Ling
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166537/
https://ncbi.nlm.nih.gov/pubmed/27994664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.16010
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