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A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major
Glyoxalase I forms part of the glyoxalase pathway that detoxifies reactive aldehydes such as methylglyoxal, using the spontaneously formed glutathione hemithioacetal as substrate. All known eukaryotic enzymes contain zinc as their metal cofactor, whereas the Escherichia coli glyoxalase I contains ni...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516525/ https://ncbi.nlm.nih.gov/pubmed/15329410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402918101 |
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