Integrin β3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin αIIbβ3 activation

Abciximab, a derivative of the murine mAb 7E3, protects against ischemic complications of percutaneous coronary interventions by inhibiting ligand binding to the αIIbβ3 receptor. In this study we identified regions on integrin β3 that control 7E3 binding. Murine/human amino acid substitutions were c...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Artoni, Andrea, Li, JiHong, Mitchell, Beau, Ruan, Jian, Takagi, Junichi, Springer, Timothy A., French, Deborah L., Coller, Barry S.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2004
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15277669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404201101
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