Integrin β3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin αIIbβ3 activation

Abciximab, a derivative of the murine mAb 7E3, protects against ischemic complications of percutaneous coronary interventions by inhibiting ligand binding to the αIIbβ3 receptor. In this study we identified regions on integrin β3 that control 7E3 binding. Murine/human amino acid substitutions were c...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Artoni, Andrea, Li, JiHong, Mitchell, Beau, Ruan, Jian, Takagi, Junichi, Springer, Timothy A., French, Deborah L., Coller, Barry S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15277669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404201101
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