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Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy

ABSTRACT: JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencin...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Takahashi, Kenta, Sekizuka, Tsuyoshi, Fukumoto, Hitomi, Nakamichi, Kazuo, Suzuki, Tadaki, Sato, Yuko, Hasegawa, Hideki, Kuroda, Makoto, Katano, Harutaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165223/
https://ncbi.nlm.nih.gov/pubmed/27795410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01335-16
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