Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase

Nonenzymatic roles for HIV-1 integrase (IN) at steps prior to the enzymatic integration step have been reported. To obtain structural and functional insights into the nonenzymatic roles of IN, we performed genetic analyses of HIV-1 IN, focusing on a highly conserved Tyr15 in the N-terminal domain (N...

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Veröffentlicht in:J Virol
Hauptverfasser: Takahata, Tatsuro, Takeda, Eri, Tobiume, Minoru, Tokunaga, Kenzo, Yokoyama, Masaru, Huang, Yu-Lun, Hasegawa, Atsuhiko, Shioda, Tatsuo, Sato, Hironori, Kannagi, Mari, Masuda, Takao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165222/
https://ncbi.nlm.nih.gov/pubmed/27795445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02003-16
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