The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport

Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis. One potential pathway involves hypochlorous acid (HOCl) produced by myeloperoxidase (MPO), a heme protein secreted...

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Dades bibliogràfiques
Autors principals: Bergt, Constanze, Pennathur, Subramaniam, Fu, Xiaoyun, Byun, Jaeman, O'Brien, Kevin, McDonald, Thomas O., Singh, Pragya, Anantharamaiah, G. M., Chait, Alan, Brunzell, John, Geary, Randolph L., Oram, John F., Heinecke, Jay W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC516512/
https://ncbi.nlm.nih.gov/pubmed/15326314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405292101
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