Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells

Dynamic spatiotemporal modification of chromatin around DNA damage is vital for efficient DNA repair. Normal stem cells exhibit an attenuated DNA damage response (DDR), inefficient DNA repair, and high radiosensitivity. The impact of unique chromatin characteristics of stem cells in DDR regulation i...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Meyer, Barbara, Fabbrizi, Maria Rita, Raj, Suyash, Zobel, Cheri L., Hallahan, Dennis E., Sharma, Girdhar G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161741/
https://ncbi.nlm.nih.gov/pubmed/27974220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.11.004
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